3PO6

Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Summary for 3PO6

• Entry DOI: 10.2210/pdb3po6/pdb
• Related: 3IGP
• Descriptor: Carbonic anhydrase 2, ZINC ION, (1S)-6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide, ... (7 entities in total)
• Functional Keywords: carbonic anhydrase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00918
• Total number of polymer chains: 1
• Total formula weight: 30223.39

Authors

Mader, P.,Brynda, J.,Gitto, R.,Agnello, S.,Ferro, S.,De Luca, L.,Vullo, D.,Supuran, C.T.,Chimirri, A. (deposition date: 2010-11-22, release date: 2011-04-06, Last modification date: 2024-03-20)

• Primary citation: Mader, P.,Brynda, J.,Gitto, R.,Agnello, S.,Pachl, P.,Supuran, C.T.,Chimirri, A.,Rezacova, P.; Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides.; J.Med.Chem., 54:2522-2526, 2011; PubMed: 21395315; DOI: 10.1021/jm2000213

Experimental method

X-RAY DIFFRACTION (1.47 Å)