3PLF

Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain

Summary for 3PLF

Entry DOI	10.2210/pdb3plf/pdb
Descriptor	MetRD peptide, E3 ubiquitin-protein ligase CBL, CALCIUM ION, ... (5 entities in total)
Functional Keywords	c-cbl tkb domain, met, reverse binding, protein binding-ligase complex, protein binding/ligase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P22681
Total number of polymer chains	4
Total formula weight	79364.84
Authors	Sun, Q.,Sivaraman, J. (deposition date: 2010-11-15, release date: 2010-12-01, Last modification date: 2023-12-06)
Primary citation	Sun, Q.,Ng, C.,Guy, G.R.,Sivaraman, J. An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding Febs Lett., 585:281-285, 2011 Cited by PubMed: 21163258 DOI: 10.1016/j.febslet.2010.11.060 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation