3PJ8

Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.

Summary for 3PJ8

Entry DOI	10.2210/pdb3pj8/pdb
Related	1G5S 1W0X 2A0C 2A4L 3DDP 3DDQ
Descriptor	Cell division protein kinase 2, (2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]amino}butan-1-ol (3 entities in total)
Functional Keywords	phosphorylation, cell division, mitosis, cyclin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34387.99
Authors	McNae, I.W.,Jorda, R.,Havlicek, L.,Strnad, M.,Voller, J.,Walkinshaw, M.D.,Krystof, V. (deposition date: 2010-11-09, release date: 2011-04-06, Last modification date: 2024-02-21)
Primary citation	Jorda, R.,McNae, I.W.,Walkinshaw, M.D.,Voller, J.,Navratilova, J.,Kuzma, M.,Mistrik, M.,Bartek, J.,Strnad, M. Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity. J.Med.Chem., 54:2980-2993, 2011 Cited by PubMed: 21417417 DOI: 10.1021/jm200064p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation