3PJ2

Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

Summary for 3PJ2

Entry DOI	10.2210/pdb3pj2/pdb
Related	3PIX 3PIY 3PIZ 3PJ1 3PJ3
Descriptor	Tyrosine-protein kinase BTK, 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
Functional Keywords	helix c-out, dfg-in, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q06187
Total number of polymer chains	1
Total formula weight	32305.05
Authors	Kuglstatter, A.,Wong, A. (deposition date: 2010-11-08, release date: 2011-01-12, Last modification date: 2023-09-06)
Primary citation	Kuglstatter, A.,Wong, A.,Tsing, S.,Lee, S.W.,Lou, Y.,Villasenor, A.G.,Bradshaw, J.M.,Shaw, D.,Barnett, J.W.,Browner, M.F. Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. Protein Sci., 20:428-436, 2011 Cited by PubMed: 21280133 DOI: 10.1002/pro.575 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation