3PIZ

Crystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone

Summary for 3PIZ

Entry DOI	10.2210/pdb3piz/pdb
Related	3PIX 3PIY 3PJ1 3PJ2 3PJ3
Descriptor	Tyrosine-protein kinase BTK, [5-amino-1-(2-methylphenyl)-1H-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone (3 entities in total)
Functional Keywords	helix c-in, dfg-in, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q06187
Total number of polymer chains	1
Total formula weight	32266.06
Authors	Kuglstatter, A.,Wong, A. (deposition date: 2010-11-08, release date: 2011-01-12, Last modification date: 2023-09-06)
Primary citation	Kuglstatter, A.,Wong, A.,Tsing, S.,Lee, S.W.,Lou, Y.,Villasenor, A.G.,Bradshaw, J.M.,Shaw, D.,Barnett, J.W.,Browner, M.F. Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. Protein Sci., 20:428-436, 2011 Cited by PubMed: 21280133 DOI: 10.1002/pro.575 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation