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3PIY

Crystal structure of BTK kinase domain complexed with R406

Summary for 3PIY
Entry DOI10.2210/pdb3piy/pdb
Related3PIX 3PIZ 3PJ1 3PJ2 3PJ3
DescriptorTyrosine-protein kinase BTK, 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (3 entities in total)
Functional Keywordshelix c-out, dfg-in, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity): Q06187
Total number of polymer chains1
Total formula weight32297.98
Authors
Kuglstatter, A.,Wong, A. (deposition date: 2010-11-08, release date: 2011-01-12, Last modification date: 2023-09-06)
Primary citationKuglstatter, A.,Wong, A.,Tsing, S.,Lee, S.W.,Lou, Y.,Villasenor, A.G.,Bradshaw, J.M.,Shaw, D.,Barnett, J.W.,Browner, M.F.
Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20:428-436, 2011
Cited by
PubMed: 21280133
DOI: 10.1002/pro.575
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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