3PIO

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit

Summary for 3PIO

Entry DOI	10.2210/pdb3pio/pdb
Related	1NKW 1SM1 1YI2 2ZJR 3JQ4 3PIP
Descriptor	RIBOSOMAL 23S RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (34 entities in total)
Functional Keywords	ribosome, large ribosomal subunit, 50s, ribonucleoprotein, ribosomal protein, rna-binding, rrna-binding, trna-binding, lankamycin, lankacidin, macrolide, ribosome-antibiotic complex, ribosome/antibiotic
Biological source	Deinococcus radiodurans R1 More
Total number of polymer chains	30
Total formula weight	1370433.47
Authors	Belousoff, M.J.,Shapira, T.,Bashan, A.,Zimmerman, E.,Arakawa, K.,Kinashi, H.,Rozenberg, H.,Yonath, A. (deposition date: 2010-11-07, release date: 2011-02-23, Last modification date: 2023-09-06)
Primary citation	Belousoff, M.J.,Shapira, T.,Bashan, A.,Zimmerman, E.,Rozenberg, H.,Arakawa, K.,Kinashi, H.,Yonath, A. Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit. Proc.Natl.Acad.Sci.USA, 108:2717-2722, 2011 Cited by PubMed: 21282615 DOI: 10.1073/pnas.1019406108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2473 Å)

Structure validation