3PGD

Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation

Summary for 3PGD

• Entry DOI: 10.2210/pdb3pgd/pdb
• Related: 3PGC
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, HLA class II histocompatibility antigen gamma chain, ... (4 entities in total)
• Functional Keywords: mhc class ii, mhc ii, immune system, self antigen, invariant chain, clip
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Cell membrane; Single-pass type II membrane protein (Potential): P04233
• Total number of polymer chains: 6
• Total formula weight: 94350.55

Authors

Gunther, S.,Schlundt, A.,Sticht, J.,Roske, Y.,Heinemann, U.,Wiesmuller, K.-H.,Jung, G.,Falk, K.,Rotzschke, O.,Freund, C. (deposition date: 2010-11-01, release date: 2010-12-08, Last modification date: 2011-07-13)

• Primary citation: Gunther, S.,Schlundt, A.,Sticht, J.,Roske, Y.,Heinemann, U.,Wiesmuller, K.H.,Jung, G.,Falk, K.,Rotzschke, O.,Freund, C.; Bidirectional binding of invariant chain peptides to an MHC class II molecule.; Proc.Natl.Acad.Sci.USA, 107:22219-22224, 2010; PubMed: 21115828; DOI: 10.1073/pnas.1014708107

Experimental method

X-RAY DIFFRACTION (2.72 Å)