3PDQ

Crystal structure of JMJD2A complexed with bipyridyl inhibitor

Summary for 3PDQ

• Entry DOI: 10.2210/pdb3pdq/pdb
• Related: 2OQ7 2OX0 2VD7 2WWJ 3NJY
• Descriptor: Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: jmjc domain, oxidoreductase, chromatin regulator, dioxygenase, transcription, iron, 2-oxoglutarate, alpha-ketoglutarate, demethylation, nucleus, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O75164
• Total number of polymer chains: 2
• Total formula weight: 89696.57

Authors

King, O.N.F.,Chang, K.-H.,Rose, N.R.,Clifton, I.J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-10-23, release date: 2011-03-30, Last modification date: 2023-11-01)

• Primary citation: Chang, K.-H.,King, O.N.F.,Tumber, A.,Woon, E.C.,Heightman, T.D.,McDonough, M.A.,Schofield, C.J.,Rose, N.R.; Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds; Chemmedchem, 6:759-764, 2011; PubMed: 21412984; DOI: 10.1002/cmdc.201100026

Experimental method

X-RAY DIFFRACTION (1.989 Å)