3PBR

Crystal structure of PBP3 complexed with meropenem

Summary for 3PBR

• Entry DOI: 10.2210/pdb3pbr/pdb
• Related: 3PBN 3PBO 3PBQ 3PBS 3PBT
• Descriptor: Penicillin-binding protein 3, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• Functional Keywords: pbp3, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 58714.93

Authors

Han, S. (deposition date: 2010-10-20, release date: 2010-12-22, Last modification date: 2012-05-16)

• Primary citation: Han, S.,Zaniewski, R.P.,Marr, E.S.,Lacey, B.M.,Tomaras, A.P.,Evdokimov, A.,Miller, J.R.,Shanmugasundaram, V.; Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.; Proc.Natl.Acad.Sci.USA, 107:22002-22007, 2010; PubMed: 21135211; DOI: 10.1073/pnas.1013092107

Experimental method

X-RAY DIFFRACTION (1.95 Å)