3PBA

Crystal structure of PPARgamma ligand binding domain in complex with monosulfate tetrabromo-bisphenol A (MonoTBBPA)

Summary for 3PBA

Entry DOI	10.2210/pdb3pba/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 2,6-dibromo-4-[2-(3,5-dibromo-4-hydroxyphenyl)propan-2-yl]phenyl hydrogen sulfate, S-1,2-PROPANEDIOL, ... (4 entities in total)
Functional Keywords	transcription, ligand binding protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	65945.52
Authors	le Maire, A.,Bourguet, W. (deposition date: 2010-10-20, release date: 2011-06-08, Last modification date: 2024-02-21)
Primary citation	Riu, A.,le Maire, A.,Grimaldi, M.,Audebert, M.,Hillenweck, A.,Bourguet, W.,Balaguer, P.,Zalko, D. Characterization of Novel Ligands of ER{alpha}, Er{beta}, and PPAR{gamma}: The Case of Halogenated Bisphenol A and Their Conjugated Metabolites. Toxicol Sci, 122:372-382, 2011 Cited by PubMed: 21622942 DOI: 10.1093/toxsci/kfr132 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation