3P9J

Aurora A kinase domain with phthalazinone pyrazole inhibitor

Summary for 3P9J

Entry DOI	10.2210/pdb3p9j/pdb
Descriptor	Serine/threonine-protein kinase 6, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1(2H)-one (3 entities in total)
Functional Keywords	phosphotransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31365.07
Authors	Kairies, N.A.,Oliveira, T.,Engh, R.A. (deposition date: 2010-10-17, release date: 2011-03-23, Last modification date: 2024-02-21)
Primary citation	Prime, M.E.,Courtney, S.M.,Brookfield, F.A.,Marston, R.W.,Walker, V.,Warne, J.,Boyd, A.E.,Kairies, N.A.,von der Saal, W.,Limberg, A.,Georges, G.,Engh, R.A.,Goller, B.,Rueger, P.,Rueth, M. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of aurora-a kinase. J.Med.Chem., 54:312-319, 2011 Cited by PubMed: 21128645 DOI: 10.1021/jm101346r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation