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3P97

Dengue 3 NS5 Methyltransferase bound to the substrate S-Adenosyl methionine

Summary for 3P97
Entry DOI10.2210/pdb3p97/pdb
Related3P8Z
DescriptorNon-structural protein 5, S-ADENOSYLMETHIONINE (3 entities in total)
Functional Keywords2'o methyltransferase, n7 methyltransferase, ns3, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceDengue virus 3
Cellular locationEnvelope protein E: Virion membrane; Multi- pass membrane protein: C1KBQ3
Total number of polymer chains2
Total formula weight60936.05
Authors
Noble, C.G.,Yap, L.J.,Lescar, J. (deposition date: 2010-10-16, release date: 2010-12-08, Last modification date: 2023-11-01)
Primary citationLim, S.P.,Sonntag, L.S.,Noble, C.,Nilar, S.H.,Ng, R.H.,Zou, G.,Monaghan, P.,Chung, K.Y.,Dong, H.,Liu, B.,Bodenreider, C.,Lee, G.,Ding, M.,Chan, W.L.,Wang, G.,Jian, Y.L.,Chao, A.T.,Lescar, J.,Yin, Z.,Vedananda, T.R.,Keller, T.H.,Shi, P.Y.
Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286:6233-6240, 2011
Cited by
PubMed: 21147775
DOI: 10.1074/jbc.M110.179184
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

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