3P95

Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant (BPTI-K15R/R17D)

Summary for 3P95

• Entry DOI: 10.2210/pdb3p95/pdb
• Related: 2R9P
• Descriptor: PRSS3 protein, Pancreatic trypsin inhibitor, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: human mesotrypsin-canonical inhibitor complex, mesotrypsin, trypsin iv, bovine pancreatic trypsin inhibitor, canonical inhibitor, bpti-k15r/r17d, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00974
• Total number of polymer chains: 2
• Total formula weight: 30811.01

Authors

Salameh, M.A.,Soares, A.S.,Radisky, E.S. (deposition date: 2010-10-15, release date: 2011-08-31, Last modification date: 2023-09-06)

• Primary citation: Salameh, M.A.,Soares, A.S.,Hockla, A.,Radisky, D.C.,Radisky, E.S.; The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity.; Biochem.J., 440:95-105, 2011; PubMed: 21806544; DOI: 10.1042/BJ20110788

Experimental method

X-RAY DIFFRACTION (1.2991 Å)