3P5S

Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex

Summary for 3P5S

• Entry DOI: 10.2210/pdb3p5s/pdb
• Related: 3GC6 3GH3 3GHH 3KOU
• Descriptor: CD38 molecule, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• Functional Keywords: cd38, cyclic adp ribose, ecto-adp-ribosyl cyclase, glycosidase, hydrolase
• Biological source: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• Total number of polymer chains: 2
• Total formula weight: 64899.41

Authors

Egea, P.F.,Muller-Stauffler, H.,Kohn, I.,Cakou-Kefir, C.,Stroud, R.M.,Kellenberburger, E.,Schuber, F. (deposition date: 2010-10-10, release date: 2011-10-19, Last modification date: 2023-09-06)

• Primary citation: Egea, P.F.,Muller-Steffner, H.,Kuhn, I.,Cakir-Kiefer, C.,Oppenheimer, N.J.,Stroud, R.M.,Kellenberger, E.,Schuber, F.; Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.; Plos One, 7:e34918-e34918, 2012; PubMed: 22529956; DOI: 10.1371/journal.pone.0034918

Experimental method

X-RAY DIFFRACTION (1.95 Å)