3P5A
Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate
Summary for 3P5A
| Entry DOI | 10.2210/pdb3p5a/pdb |
| Related | 3P58 3P5L |
| Descriptor | Carbonic anhydrase 2, ZINC ION, morpholine-4-carbodithioic acid, ... (5 entities in total) |
| Functional Keywords | carbothioates, hcaii inhibitors, lyase-inhibitor complex, lyase/inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29595.87 |
| Authors | Aggarwal, M.,McKenna, R. (deposition date: 2010-10-08, release date: 2011-10-19, Last modification date: 2024-02-21) |
| Primary citation | Carta, F.,Aggarwal, M.,Maresca, A.,Scozzafava, A.,McKenna, R.,Masini, E.,Supuran, C.T. Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo J.Med.Chem., 55:1721-1730, 2012 Cited by PubMed: 22276570DOI: 10.1021/jm300031j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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