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3P3S

Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one

Summary for 3P3S
Entry DOI10.2210/pdb3p3s/pdb
Related3IMR 3IMS 3IMT 3IMU 3P3R 3P3T 3P3U
DescriptorTransthyretin, (5Z)-2-amino-5-(3,5-dibromo-4-hydroxybenzylidene)-1-methyl-1,5-dihydro-4H-imidazol-4-one (3 entities in total)
Functional Keywordshormone, t4, retinol binding protein, hormone-binding protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight29054.78
Authors
Connelly, S.,Wilson, I.A. (deposition date: 2010-10-05, release date: 2011-08-24, Last modification date: 2023-09-06)
Primary citationAlhamadsheh, M.M.,Connelly, S.,Cho, A.,Reixach, N.,Powers, E.T.,Pan, D.W.,Wilson, I.A.,Kelly, J.W.,Graef, I.A.
Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Sci Transl Med, 3:97ra81-97ra81, 2011
Cited by
PubMed: 21865539
DOI: 10.1126/scitranslmed.3002473
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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