3OY1

Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties

Summary for 3OY1

Entry DOI	10.2210/pdb3oy1/pdb
Descriptor	Mitogen-activated protein kinase 10, 5-[2-(cyclohexylamino)pyridin-4-yl]-4-naphthalen-2-yl-2-(tetrahydro-2H-pyran-4-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one (3 entities in total)
Functional Keywords	kinase inhibitor, cns, selectivity, transferase, transherase-transferase inhibitor complex, transherase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P53779
Total number of polymer chains	1
Total formula weight	42268.94
Authors	Probst, G.D.,Bowers, S.,Sealy, J.M.,Truong, A.,Neitz, J.,Hom, R.K.,Galemmo Jr., R.A.,Konradi, A.W.,Sham, H.L.,Quincy, D.,Pan, H.,Yao, N. (deposition date: 2010-09-22, release date: 2011-08-17, Last modification date: 2024-02-21)
Primary citation	Probst, G.D.,Bowers, S.,Sealy, J.M.,Truong, A.P.,Hom, R.K.,Galemmo, R.A.,Konradi, A.W.,Sham, H.L.,Quincy, D.A.,Pan, H.,Yao, N.,Lin, M.,Toth, G.,Artis, D.R.,Zmolek, W.,Wong, K.,Qin, A.,Lorentzen, C.,Nakamura, D.F.,Quinn, K.P.,Sauer, J.M.,Powell, K.,Ruslim, L.,Wright, S.,Chereau, D.,Ren, Z.,Anderson, J.P.,Bard, F.,Yednock, T.A.,Griswold-Prenner, I. Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg.Med.Chem.Lett., 21:315-319, 2011 Cited by PubMed: 21112785 DOI: 10.1016/j.bmcl.2010.11.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation