3OWJ

Human CK2 catalytic domain in complex with a pyridocarbazole derivative inhibitor

Summary for 3OWJ

Entry DOI	10.2210/pdb3owj/pdb
Related	3MB6 3MB7 3OWK 3OWL
Descriptor	CSNK2A1 protein, 9-hydroxy-5,11-dimethyl-4,6-dihydro-1H-pyrido[4,3-b]carbazol-1-one (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, ck2, inhibitor, pyridocarbazole, ellipticine, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39928.53
Authors	Reiser, J.-B.,Prudent, R.,Cochet, C. (deposition date: 2010-09-20, release date: 2010-12-15, Last modification date: 2024-02-21)
Primary citation	Prudent, R.,Moucadel, V.,Nguyen, C.H.,Barette, C.,Schmidt, F.,Florent, J.C.,Lafanechere, L.,Sautel, C.F.,Duchemin-Pelletier, E.,Spreux, E.,Filhol, O.,Reiser, J.B.,Cochet, C. Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2. Cancer Res., 70:9865-9874, 2010 Cited by PubMed: 21118972 DOI: 10.1158/0008-5472.CAN-10-0917 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation