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3OW3

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Summary for 3OW3
Entry DOI10.2210/pdb3ow3/pdb
Related3OW4
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine, ... (4 entities in total)
Functional Keywordscyclic-amp dependent protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMus musculus (mouse)
More
Cellular locationCytoplasm: P05132
Total number of polymer chains2
Total formula weight43306.27
Authors
Dizon, F.,Wu, W.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-09-17, release date: 2010-11-10, Last modification date: 2023-09-06)
Primary citationBencsik, J.R.,Xiao, D.,Blake, J.F.,Kallan, N.C.,Mitchell, I.S.,Spencer, K.L.,Xu, R.,Gloor, S.L.,Martinson, M.,Risom, T.,Woessner, R.D.,Dizon, F.,Wu, W.I.,Vigers, G.P.,Brandhuber, B.J.,Skelton, N.J.,Prior, W.W.,Murray, L.J.
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.
Bioorg.Med.Chem.Lett., 20:7037-7041, 2010
Cited by
PubMed: 20971641
DOI: 10.1016/j.bmcl.2010.09.112
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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