3OV1

Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide

Summary for 3OV1

Entry DOI	10.2210/pdb3ov1/pdb
Related	2H5K 3IMD 3IMJ 3IN7 3IN8 3KFJ 3OVE 3OVF 3S8L 3S8N 3S8O
Descriptor	Growth factor receptor-bound protein 2, PYAC3CN, GLYCEROL, ... (6 entities in total)
Functional Keywords	grb2 sh2 domain, phosphotyrosine binding, signaling protein, signaling protein-antagonist complex, signaling protein/antagonist
Biological source	Homo sapiens
Cellular location	Nucleus: P62993
Total number of polymer chains	2
Total formula weight	14509.14
Authors	Clements, J.H.,Martin, S.F. (deposition date: 2010-09-15, release date: 2011-11-02, Last modification date: 2023-12-06)
Primary citation	Myslinski, J.M.,Delorbe, J.E.,Clements, J.H.,Martin, S.F. Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133:18518-18521, 2011 Cited by PubMed: 22007755 DOI: 10.1021/ja2068752 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation