3ORZ

PDK1 mutant bound to allosteric disulfide fragment activator 2A2

Summary for 3ORZ

Entry DOI	10.2210/pdb3orz/pdb
Related	3ORX 3OTU
Descriptor	3-phosphoinositide-dependent protein kinase 1, 4-[4-(3-chlorophenyl)piperazin-1-yl]-4-oxobutane-1-thiol, 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE, ... (4 entities in total)
Functional Keywords	c helix, ser/thr-kinase, agc kinase, allostery, transferase, allosteric activator, bisindolylmaleimide, disulfide, kinase, pdk1, transferase-transferase activator complex, transferase/transferase activator
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	4
Total formula weight	147659.24
Authors	Sadowsky, J.D.,Wells, J.A. (deposition date: 2010-09-08, release date: 2011-03-23, Last modification date: 2023-09-06)
Primary citation	Sadowsky, J.D.,Burlingame, M.A.,Wolan, D.W.,McClendon, C.L.,Jacobson, M.P.,Wells, J.A. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc.Natl.Acad.Sci.USA, 108:6056-6061, 2011 Cited by PubMed: 21430264 DOI: 10.1073/pnas.1102376108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9995 Å)

Structure validation