3ORX

PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8

Summary for 3ORX

Entry DOI	10.2210/pdb3orx/pdb
Descriptor	3-phosphoinositide-dependent protein kinase 1, 2-methyl-N-(2-sulfanylethyl)-1-benzofuran-3-carboxamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	pif pocket, c-helix, activation loop, agc kinase, transferase, allosteric inhibitor, phosphorylation, allostery, disulfide, kinase, pdk1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	8
Total formula weight	291443.88
Authors	Sadowsky, J.D.,Wells, J.A. (deposition date: 2010-09-08, release date: 2011-03-23, Last modification date: 2023-09-06)
Primary citation	Sadowsky, J.D.,Burlingame, M.A.,Wolan, D.W.,McClendon, C.L.,Jacobson, M.P.,Wells, J.A. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc.Natl.Acad.Sci.USA, 108:6056-6061, 2011 Cited by PubMed: 21430264 DOI: 10.1073/pnas.1102376108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2044 Å)

Structure validation