3OJ2

Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation

Summary for 3OJ2

Entry DOI	10.2210/pdb3oj2/pdb
Related	1DJS 1EVT 1RY7 3OJM 3OJV
Descriptor	Heparin-binding growth factor 1, Fibroblast growth factor receptor 2, SULFATE ION, ... (4 entities in total)
Functional Keywords	beta trefoil motif, immunoglobulin-like domain, growth factor, growth factor receptor, extracellular, cytokine-signaling protein complex, cytokine/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P05230 Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains	4
Total formula weight	87400.40
Authors	Beenken, A.,Mohammadi, M. (deposition date: 2010-08-20, release date: 2011-08-31, Last modification date: 2023-09-06)
Primary citation	Beenken, A.,Eliseenkova, A.V.,Ibrahimi, O.A.,Olsen, S.K.,Mohammadi, M. Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287:3067-3078, 2012 Cited by PubMed: 22057274 DOI: 10.1074/jbc.M111.275891 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation