3OHT

Crystal Structure of Salmo Salar p38alpha

Summary for 3OHT

Entry DOI	10.2210/pdb3oht/pdb
Descriptor	p38a, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase serine/threonine-protein kinase transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Salmo salar (Atlantic salmon)
Total number of polymer chains	2
Total formula weight	92060.12
Authors	Rothweiler, U.,Johnson, K.,Engh, R.A. (deposition date: 2010-08-18, release date: 2011-06-29, Last modification date: 2023-09-06)
Primary citation	Rothweiler, U.,Aberg, E.,Johnson, K.A.,Hansen, T.E.,Jorgensen, J.B.,Engh, R.A. p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation J.Mol.Biol., 411:474-485, 2011 Cited by PubMed: 21699901 DOI: 10.1016/j.jmb.2011.06.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation