3OCG

P38 Alpha kinase complexed with a 5-amino-pyrazole based inhibitor

Summary for 3OCG

Entry DOI	10.2210/pdb3ocg/pdb
Descriptor	Mitogen-activated protein kinase 14, 5-amino-N-[5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl]-1-phenyl-1H-pyrazole-4-carboxamide (3 entities in total)
Functional Keywords	p38 map kinase, serine/threonine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42507.41
Authors	Sack, J.S. (deposition date: 2010-08-10, release date: 2010-11-17, Last modification date: 2024-02-21)
Primary citation	Das, J.,Moquin, R.V.,Dyckman, A.J.,Li, T.,Pitt, S.,Zhang, R.,Shen, D.R.,McIntyre, K.W.,Gillooly, K.,Doweyko, A.M.,Newitt, J.A.,Sack, J.S.,Zhang, H.,Kiefer, S.E.,Kish, K.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K. 5-Amino-pyrazoles as potent and selective p38α inhibitors Bioorg.Med.Chem.Lett., 20:6886-6889, 2010 Cited by PubMed: 21035336 DOI: 10.1016/j.bmcl.2010.10.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation