3OAD

Design and optimization of new piperidines as renin inhibitors

Summary for 3OAD

• Entry DOI: 10.2210/pdb3oad/pdb
• Related: 3OAG 3OL9
• Descriptor: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,4R)-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-4-{6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridin-3-yl}-4-hydroxypiperidine-3-carboxamide, ... (5 entities in total)
• Functional Keywords: protease, blood, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00797 P00797
• Total number of polymer chains: 4
• Total formula weight: 77079.50

Authors

Prade, L. (deposition date: 2010-08-05, release date: 2010-11-03, Last modification date: 2020-07-29)

• Primary citation: Corminboeuf, O.,Bezencon, O.,Grisostomi, C.,Remen, L.,Richard-Bildstein, S.,Bur, D.,Prade, L.,Hess, P.,Strickner, P.,Fischli, W.,Steiner, B.,Treiber, A.; Design and optimization of new piperidines as renin inhibitors.; Bioorg.Med.Chem.Lett., 20:6286-6290, 2010; PubMed: 20843686; DOI: 10.1016/j.bmcl.2010.08.086

Experimental method

X-RAY DIFFRACTION (2.17 Å)