3O4U

Crystal Structure of HePTP with an Atypically Open WPD Loop

Summary for 3O4U

Entry DOI	10.2210/pdb3o4u/pdb
Related	1ZC0 2GP0 2HVL 2QDC 2QDM 2QDP 3D42 3D44 3O4S 3O4T
Descriptor	Tyrosine-protein phosphatase non-receptor type 7, L(+)-TARTARIC ACID, S,R MESO-TARTARIC ACID, ... (5 entities in total)
Functional Keywords	heptp, human hematopoietic tyrosine phosphatase catalytic domain mutant, lc-ptp, ptpn7, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P35236
Total number of polymer chains	1
Total formula weight	35717.16
Authors	Critton, D.A.,Page, R. (deposition date: 2010-07-27, release date: 2010-11-24, Last modification date: 2023-09-06)
Primary citation	Critton, D.A.,Tautz, L.,Page, R. Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop. J.Mol.Biol., 405:619-629, 2011 Cited by PubMed: 21094165 DOI: 10.1016/j.jmb.2010.11.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation