3NZA

Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of Five Potent 5-(omega-Carboxy(alkyloxy)pyrido[2,3-d]pyrimidine Derivatives

Summary for 3NZA

Entry DOI	10.2210/pdb3nza/pdb
Related	2fzh 2fzi 2fzj 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZ6 3NZ9 3NZA 3NZB 3NZC 3NZD
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ethyl 4-{3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}butanoate, ... (5 entities in total)
Functional Keywords	pneumocystsis carinii dihydrofolare reductase inhibitor complexes, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Pneumocystis carinii
Total number of polymer chains	1
Total formula weight	25124.89
Authors	Cody, V. (deposition date: 2010-07-16, release date: 2010-12-29, Last modification date: 2023-09-06)
Primary citation	Cody, V.,Pace, J. Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-([omega]-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives Acta Crystallogr.,Sect.D, 67:1-7, 2011 Cited by PubMed: 21206056 DOI: 10.1107/S0907444910041004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation