3NXV

Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase

Summary for 3NXV

Entry DOI	10.2210/pdb3nxv/pdb
Related	3NXO 3NXR 3NXT 3NXX 3NXY 3NZ6 3NZ9 3NZA 3NZB 3NZC 3NZD 3d7x 3d7y 3gyf
Descriptor	Dihydrofolate reductase, 5-[(1E)-2-(2-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	chiral mixture, e-z-isomers, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	1
Total formula weight	22529.41
Authors	Cody, V. (deposition date: 2010-07-14, release date: 2010-12-01, Last modification date: 2024-04-03)
Primary citation	Cody, V.,Piraino, J.,Pace, J.,Li, W.,Gangjee, A. Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 66:1271-1277, 2010 Cited by PubMed: 21123866 DOI: 10.1107/S0907444910035808 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation