3NWW

P38 Alpha kinase complexed with a 2-aminothiazol-5-yl-pyrimidine based inhibitor

Summary for 3NWW

Entry DOI	10.2210/pdb3nww/pdb
Descriptor	Mitogen-activated protein kinase 14, 1-[2-(2-{[2-(dimethylamino)ethyl]amino}-6-{2-[(1-methylethyl)amino]-1,3-thiazol-5-yl}pyrimidin-4-yl)benzyl]-3-ethylurea (3 entities in total)
Functional Keywords	p38 map kinase, serine/threonine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42587.65
Authors	Sack, J.S. (deposition date: 2010-07-12, release date: 2010-09-08, Last modification date: 2024-02-21)
Primary citation	Lin, S.,Wrobleski, S.T.,Hynes, J.,Pitt, S.,Zhang, R.,Fan, Y.,Doweyko, A.M.,Kish, K.F.,Sack, J.S.,Malley, M.F.,Kiefer, S.E.,Newitt, J.A.,McKinnon, M.,Trzaskos, J.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K. Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38alpha MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 20:5864-5868, 2010 Cited by PubMed: 20732813 DOI: 10.1016/j.bmcl.2010.07.102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation