3NW5

Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (11B)

Summary for 3NW5

Entry DOI	10.2210/pdb3nw5/pdb
Related	3NW6 3NW7
Descriptor	Insulin-like growth factor 1 receptor, N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{(2R)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine (3 entities in total)
Functional Keywords	hormone/growth factor, igf-1r, kinase domain, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P08069
Total number of polymer chains	1
Total formula weight	35473.68
Authors	Sack, J.S. (deposition date: 2010-07-09, release date: 2010-07-28, Last modification date: 2024-02-21)
Primary citation	Sampognaro, A.J.,Wittman, M.D.,Carboni, J.M.,Chang, C.,Greer, A.F.,Hurlburt, W.W.,Sack, J.S.,Vyas, D.M. Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase. Bioorg.Med.Chem.Lett., 20:5027-5030, 2010 Cited by PubMed: 20675137 DOI: 10.1016/j.bmcl.2010.07.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation