3NUP

CDK6 (monomeric) in complex with inhibitor

Summary for 3NUP

Entry DOI	10.2210/pdb3nup/pdb
Related	3NUX
Descriptor	Cell division protein kinase 6, 4-[3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(1-methylpiperidin-4-yl)pyrimidin-2-amine (3 entities in total)
Functional Keywords	kinase, protein kinase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q00534
Total number of polymer chains	1
Total formula weight	35319.62
Authors	Chopra, R. (deposition date: 2010-07-07, release date: 2010-12-22, Last modification date: 2024-04-03)
Primary citation	Cho, Y.S.,Borland, M.,Brain, C.,Chen, C.H.,Cheng, H.,Chopra, R.,Chung, K.,Groarke, J.,He, G.,Hou, Y.,Kim, S.,Kovats, S.,Lu, Y.,O'Reilly, M.,Shen, J.,Smith, T.,Trakshel, G.,Vogtle, M.,Xu, M.,Xu, M.,Sung, M.J. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J.Med.Chem., 53:7938-7957, 2010 Cited by PubMed: 21038853 DOI: 10.1021/jm100571n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation