3NTP

Human Pin1 complexed with reduced amide inhibitor

Summary for 3NTP

• Entry DOI: 10.2210/pdb3ntp/pdb
• Related: 2itk 2q5A
• Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, (2R)-2-(acetylamino)-3-[(2S)-2-{[2-(1H-indol-3-yl)ethyl]carbamoyl}pyrrolidin-1-yl]propyl dihydrogen phosphate, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... (4 entities in total)
• Functional Keywords: prolyl isomerase, phosphorylation regulation, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q13526
• Total number of polymer chains: 1
• Total formula weight: 19347.40

Authors

Zhang, Y. (deposition date: 2010-07-05, release date: 2012-01-04, Last modification date: 2024-04-03)

• Primary citation: Xu, G.G.,Zhang, Y.,Mercedes-Camacho, A.Y.,Etzkorn, F.A.; A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.; Biochemistry, 50:9545-9550, 2011; PubMed: 21980916; DOI: 10.1021/bi201055c

Experimental method

X-RAY DIFFRACTION (1.762 Å)