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3NS9

Crystal structure of CDK2 in complex with inhibitor BS-194

Summary for 3NS9
Entry DOI10.2210/pdb3ns9/pdb
DescriptorCell division protein kinase 2, (2S,3S)-3-{[7-(benzylamino)-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino}butane-1,2,4-triol (3 entities in total)
Functional Keywordsprotein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight34361.95
Authors
Hazel, P.,Freemont, P.S. (deposition date: 2010-07-01, release date: 2010-12-08, Last modification date: 2023-09-06)
Primary citationHeathcote, D.A.,Patel, H.,Kroll, S.H.,Hazel, P.,Periyasamy, M.,Alikian, M.,Kanneganti, S.K.,Jogalekar, A.S.,Scheiper, B.,Barbazanges, M.,Blum, A.,Brackow, J.,Siwicka, A.,Pace, R.D.,Fuchter, M.J.,Snyder, J.P.,Liotta, D.C.,Freemont, P.S.,Aboagye, E.O.,Coombes, R.C.,Barrett, A.G.,Ali, S.
A Novel Pyrazolo[1,5-a]pyrimidine Is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration.
J.Med.Chem., 53:8508-8522, 2010
Cited by
PubMed: 21080703
DOI: 10.1021/jm100732t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.78 Å)
Structure validation

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