3NJY
Crystal structure of JMJD2A complexed with 5-carboxy-8-hydroxyquinoline
Summary for 3NJY
Entry DOI | 10.2210/pdb3njy/pdb |
Related | 2GF7 2GFA 2GP3 2GP5 2VD7 2WWJ |
Descriptor | Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | oxidoreductase, chromatin regulator, transcription regulation, double-stranded beta helix, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O75164 |
Total number of polymer chains | 2 |
Total formula weight | 89279.08 |
Authors | King, O.N.F.,Clifton, I.J.,Wang, M.,Maloney, D.J.,Jadhav, A.,Oppermann, U.,Heightman, T.D.,Simeonov, A.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-06-18, release date: 2010-12-08, Last modification date: 2023-11-01) |
Primary citation | King, O.N.F.,Li, X.S.,Sakurai, M.,Kawamura, A.,Rose, N.R.,Ng, S.S.,Quinn, A.M.,Rai, G.,Mott, B.T.,Beswick, P.,Klose, R.J.,Oppermann, U.,Jadhav, A.,Heightman, T.D.,Maloney, D.J.,Schofield, C.J.,Simeonov, A. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors Plos One, 5:e15535-e15535, 2010 Cited by PubMed: 21124847DOI: 10.1371/journal.pone.0015535 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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