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3NJY

Crystal structure of JMJD2A complexed with 5-carboxy-8-hydroxyquinoline

Summary for 3NJY
Entry DOI10.2210/pdb3njy/pdb
Related2GF7 2GFA 2GP3 2GP5 2VD7 2WWJ
DescriptorLysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
Functional Keywordsoxidoreductase, chromatin regulator, transcription regulation, double-stranded beta helix, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O75164
Total number of polymer chains2
Total formula weight89279.08
Authors
King, O.N.F.,Clifton, I.J.,Wang, M.,Maloney, D.J.,Jadhav, A.,Oppermann, U.,Heightman, T.D.,Simeonov, A.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-06-18, release date: 2010-12-08, Last modification date: 2023-11-01)
Primary citationKing, O.N.F.,Li, X.S.,Sakurai, M.,Kawamura, A.,Rose, N.R.,Ng, S.S.,Quinn, A.M.,Rai, G.,Mott, B.T.,Beswick, P.,Klose, R.J.,Oppermann, U.,Jadhav, A.,Heightman, T.D.,Maloney, D.J.,Schofield, C.J.,Simeonov, A.
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
Plos One, 5:e15535-e15535, 2010
Cited by
PubMed: 21124847
DOI: 10.1371/journal.pone.0015535
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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