3NEX

V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24)

Summary for 3NEX

• Entry DOI: 10.2210/pdb3nex/pdb
• Related: 3KGS 3KGT 3KGU 3NEE 3NEO 3NES
• Descriptor: Transthyretin, GLYCEROL, [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID, ... (4 entities in total)
• Functional Keywords: transport protein, ttr, transthyretin, amyloid, gc-1, gc-24
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 26407.64

Authors

Trivella, D.B.B.,Polikarpov, I. (deposition date: 2010-06-09, release date: 2010-11-24, Last modification date: 2024-02-21)

• Primary citation: Trivella, D.B.,Sairre, M.I.,Foguel, D.,Lima, L.M.,Polikarpov, I.; The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition.; J.Struct.Biol., 173:323-332, 2011; PubMed: 20937391; DOI: 10.1016/j.jsb.2010.10.003

Experimental method

X-RAY DIFFRACTION (1.7 Å)