3NB5

Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide

Summary for 3NB5

Entry DOI	10.2210/pdb3nb5/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide, ... (5 entities in total)
Functional Keywords	drug design, natural product, sulfamate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29999.59
Authors	Hofmann, A.,Osman, A.,Davis, R.A. (deposition date: 2010-06-02, release date: 2011-04-20, Last modification date: 2023-11-01)
Primary citation	Davis, R.A.,Hofmann, A.,Osman, A.,Hall, R.A.,Muhlschlegel, F.A.,Vullo, D.,Innocenti, A.,Supuran, C.T.,Poulsen, S.A. Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases J.Med.Chem., 54:1682-1692, 2011 Cited by PubMed: 21332115 DOI: 10.1021/jm1013242 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation