3NAX

PDK1 in complex with inhibitor MP7

Summary for 3NAX

• Entry DOI: 10.2210/pdb3nax/pdb
• Related: 3NAY
• Descriptor: 3-phosphoinositide-dependent protein kinase 1, 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide (3 entities in total)
• Functional Keywords: kinase, serine/threonine protein kinase, transferase
• Biological source: Homo sapiens
• Cellular location: Cytoplasm: O15530
• Total number of polymer chains: 1
• Total formula weight: 36610.96

Authors

Yan, Y.,Munshi, S.K.,Allison, T. (deposition date: 2010-06-02, release date: 2010-11-24, Last modification date: 2024-02-21)

• Primary citation: Nagashima, K.,Shumway, S.D.,Sathyanarayanan, S.,Chen, A.H.,Dolinski, B.,Xu, Y.,Keilhack, H.,Nguyen, T.,Wiznerowicz, M.,Li, L.,Lutterbach, B.A.,Chi, A.,Paweletz, C.,Allison, T.,Yan, Y.,Munshi, S.K.,Klippel, A.,Kraus, M.,Bobkova, E.V.,Deshmukh, S.,Xu, Z.,Mueller, U.,Szewczak, A.A.,Pan, B.S.,Richon, V.,Pollock, R.,Blume-Jensen, P.,Northrup, A.,Andersen, J.N.; Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.; J.Biol.Chem., 286:6433-6448, 2011; PubMed: 21118801; DOI: 10.1074/jbc.M110.156463

Experimental method

X-RAY DIFFRACTION (1.75 Å)