3N9S

Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(4-hydroxybutyl)- glycolohydroxamic acid bis-phosphate, a competitive inhibitor

Summary for 3N9S

Entry DOI	10.2210/pdb3n9s/pdb
Related	3C4U 3C52 3C56 3N9R
Descriptor	Fructose-bisphosphate aldolase, 4-{hydroxy[(phosphonooxy)acetyl]amino}butyl dihydrogen phosphate, ZINC ION, ... (6 entities in total)
Functional Keywords	fbp aldolase, class ii, inhibitor, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Helicobacter pylori
Total number of polymer chains	2
Total formula weight	68504.84
Authors	Coincon, M.,Sygusch, S. (deposition date: 2010-05-31, release date: 2010-11-17, Last modification date: 2023-09-06)
Primary citation	Daher, R.,Fonvielle, M.,Gest, P.M.,Guerin, M.E.,Jackson, M.,Sygusch, J.,Therisod, M. Rational Design, Synthesis, and Evaluation of New Selective Inhibitors of Microbial Class II (Zinc Dependent) Fructose Bis-phosphate Aldolases. J.Med.Chem., 53:7836-7842, 2010 Cited by PubMed: 20929256 DOI: 10.1021/jm1009814 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation