3N7A

Crystal structure of 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with inhibitor 2

Summary for 3N7A

• Entry DOI: 10.2210/pdb3n7a/pdb
• Related: 3N76 3N86 3N87 3N8N
• Descriptor: 3-dehydroquinate dehydratase, 2,3 -ANHYDRO-QUINIC ACID, GLYCEROL, ... (4 entities in total)
• Functional Keywords: dehydroquinate dehydratase, mycobacterium tuberculosis, shikimate pathway, drug discovery, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 24
• Total formula weight: 384767.21

Authors

Dias, M.V.B.,Snee, W.C.,Bromfield, K.M.,Payne, R.,Palaninathan, S.K.,Ciulli, A.,Howard, N.I.,Abell, C.,Sacchettini, J.C.,Blundell, T.L. (deposition date: 2010-05-26, release date: 2011-05-11, Last modification date: 2023-09-06)

• Primary citation: Dias, M.V.,Snee, W.C.,Bromfield, K.M.,Payne, R.J.,Palaninathan, S.K.,Ciulli, A.,Howard, N.I.,Abell, C.,Sacchettini, J.C.,Blundell, T.L.; Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.; Biochem.J., 436:729-739, 2011; PubMed: 21410435; DOI: 10.1042/BJ20110002

Experimental method

X-RAY DIFFRACTION (2 Å)