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3N2P

Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor

Summary for 3N2P
Entry DOI10.2210/pdb3n2p/pdb
Related3MZC 3N0N 3N3J 3N4B
DescriptorCarbonic anhydrase 2, ZINC ION, 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide, ... (6 entities in total)
Functional Keywordslyase, zinc metalloenzyme, zinc ligands, benzenesulfonamide, inhibitor., lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceHomo sapiens
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight29861.02
Authors
Avvaru, B.S.,Wagner, J.,Robbins, A.H.,McKenna, R. (deposition date: 2010-05-18, release date: 2011-03-09, Last modification date: 2023-09-06)
Primary citationPacchiano, F.,Aggarwal, M.,Avvaru, B.S.,Robbins, A.H.,Scozzafava, A.,McKenna, R.,Supuran, C.T.
Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chem.Commun.(Camb.), 46:8371-8373, 2010
Cited by
PubMed: 20922253
DOI: 10.1039/c0cc02707c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.648 Å)
Structure validation

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