3N00

Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR ID1 peptide determined to 2.60A

Summary for 3N00

• Entry DOI: 10.2210/pdb3n00/pdb
• Related: 2vov 3cqv
• Descriptor: Rev-erbA-alpha, Nuclear receptor corepressor 1 (3 entities in total)
• Functional Keywords: reverba ncorid1, anti-parallel b-sheet, transcription regulator
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P20393 O75376
• Total number of polymer chains: 2
• Total formula weight: 30082.32

Authors

Gampe, R.,Nolte, R. (deposition date: 2010-05-13, release date: 2010-06-30, Last modification date: 2023-09-06)

• Primary citation: Phelan, C.A.,Gampe, R.T.,Lambert, M.H.,Parks, D.J.,Montana, V.,Bynum, J.,Broderick, T.M.,Hu, X.,Williams, S.P.,Nolte, R.T.,Lazar, M.A.; Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.; Nat.Struct.Mol.Biol., 17:808-814, 2010; PubMed: 20581824; DOI: 10.1038/nsmb.1860

Experimental method

X-RAY DIFFRACTION (2.6 Å)