3MYJ
Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) (R1Y) peptide variant.
Summary for 3MYJ
Entry DOI | 10.2210/pdb3myj/pdb |
Related | 1TVB 3HPJ |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Wilms tumor protein, ... (5 entities in total) |
Functional Keywords | wt-1 peptide, r1y mutation, nonapeptide, mhc class i, hla-a2, cancer vaccine, disulfide bond, glycoprotein, host-virus interaction, immune response, membrane, mhc i, phosphoprotein, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted . Note=(Microbial infection) In the presence of M: P61769 Nucleus . Isoform 1: Nucleus speckle . Isoform 4: Nucleus, nucleoplasm : P19544 |
Total number of polymer chains | 6 |
Total formula weight | 89789.81 |
Authors | Borbulevych, O.Y.,Baker, B.M. (deposition date: 2010-05-10, release date: 2010-08-18, Last modification date: 2023-09-06) |
Primary citation | Borbulevych, O.Y.,Do, P.,Baker, B.M. Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A*0201: Implications for WT1-based cancer therapeutics. Mol.Immunol., 47:2519-2524, 2010 Cited by PubMed: 20619457DOI: 10.1016/j.molimm.2010.06.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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