3MTC

Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate

Summary for 3MTC

Entry DOI	10.2210/pdb3mtc/pdb
Related	3N9V 3NR8
Descriptor	Type II inositol-1,4,5-trisphosphate 5-phosphatase, GLYCEROL, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	inpp5ba, phosphoinositide 5-phosphatase, inositol signalling, phosphatase, magnesium, structural genomics, sgc, sgc stockholm, structural genomics consortium, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol: P32019
Total number of polymer chains	1
Total formula weight	37207.68
Authors	Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kol, S.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,van der Berg, S.,Wahlberg, E.,Weigelt, J.,Wisniewska, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2010-04-30, release date: 2010-06-30, Last modification date: 2023-09-06)
Primary citation	Tresaugues, L.,Silvander, C.,Flodin, S.,Welin, M.,Nyman, T.,Graslund, S.,Hammarstrom, M.,Berglund, H.,Nordlund, P. Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases Structure, 22:744-755, 2014 Cited by PubMed: 24704254 DOI: 10.1016/j.str.2014.01.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation