3MRI

Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081 nonapeptide G4M-V5W variant

Summary for 3MRI

• Entry DOI: 10.2210/pdb3mri/pdb
• Related: 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, 9-meric peptide from Serine protease/NTPase/helicase NS3, ... (4 entities in total)
• Functional Keywords: mhc class i, hla, immune system, immune response, nonapeptide, viral peptide, hepatitis c virus, ns3 protein
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q03463
• Total number of polymer chains: 3
• Total formula weight: 47043.48

Authors

Reiser, J.-B.,Le Gorrec, M.,Chouquet, A.,Debeaupuis, E.,Echasserieau, K.,Saulquin, X.,Bonneville, M.,Housset, D. (deposition date: 2010-04-29, release date: 2011-05-25, Last modification date: 2023-11-01)

• Primary citation: Reiser, J.-B.,Le Gorrec, M.,Chouquet, A.,Debeaupuis, E.,Echasserieau, K.,Saulquin, X.,Bonneville, M.,Housset, D.; Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081 nonapeptide G4M-V5W variant; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)