3MPM
LCK complexed with a pyrazolopyrimidine
Summary for 3MPM
Entry DOI | 10.2210/pdb3mpm/pdb |
Descriptor | Tyrosine-protein kinase Lck, 4-{(6R,7R)-7-amino-3-[3-(4-methylpiperazin-1-yl)phenyl]-6,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl}phenol, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | kinase domain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P06239 |
Total number of polymer chains | 1 |
Total formula weight | 31120.71 |
Authors | Cowan-Jacob, S.W.,Rummel, G. (deposition date: 2010-04-27, release date: 2010-06-02, Last modification date: 2024-02-21) |
Primary citation | Gommermann, N.,Buehlmayer, P.,von Matt, A.,Breitenstein, W.,Masuya, K.,Pirard, B.,Furet, P.,Cowan-Jacob, S.W.,Weckbecker, G. New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck. Bioorg.Med.Chem.Lett., 20:3628-3631, 2010 Cited by PubMed: 20483608DOI: 10.1016/j.bmcl.2010.04.112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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