3MO2

human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67

Summary for 3MO2

Entry DOI	10.2210/pdb3mo2/pdb
Related	3FPD 3MO0 3MO5
Descriptor	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ZINC ION, 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, ... (5 entities in total)
Functional Keywords	epigenetics, histone lysine methylation, enzymatic inhibition, lysine mimics, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9H9B1
Total number of polymer chains	4
Total formula weight	135335.25
Authors	Chang, Y.,Horton, J.R.,Cheng, X. (deposition date: 2010-04-22, release date: 2010-06-30, Last modification date: 2023-09-06)
Primary citation	Chang, Y.,Ganesh, T.,Horton, J.R.,Spannhoff, A.,Liu, J.,Sun, A.,Zhang, X.,Bedford, M.T.,Shinkai, Y.,Snyder, J.P.,Cheng, X. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400:1-7, 2010 Cited by PubMed: 20434463 DOI: 10.1016/j.jmb.2010.04.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation