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3MO0

Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11

Summary for 3MO0
Entry DOI10.2210/pdb3mo0/pdb
Related3FPD 3MO2 3MO5
DescriptorHistone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine, ... (6 entities in total)
Functional Keywordsepigenetics, histone lysine methylation, enzymatic inhibition, lysine mimics, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q9H9B1
Total number of polymer chains2
Total formula weight68643.38
Authors
Chang, Y.,Horton, J.R.,Cheng, X. (deposition date: 2010-04-22, release date: 2010-06-30, Last modification date: 2023-09-06)
Primary citationChang, Y.,Ganesh, T.,Horton, J.R.,Spannhoff, A.,Liu, J.,Sun, A.,Zhang, X.,Bedford, M.T.,Shinkai, Y.,Snyder, J.P.,Cheng, X.
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400:1-7, 2010
Cited by
PubMed: 20434463
DOI: 10.1016/j.jmb.2010.04.048
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.78 Å)
Structure validation

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