3MME

Structure and functional dissection of PG16, an antibody with broad and potent neutralization of HIV-1

Summary for 3MME

Entry DOI	10.2210/pdb3mme/pdb
Related	3LRS
Descriptor	PG16 HEAVY CHAIN FAB, PG16 LIGHT CHAIN FAB, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	neutralizing antibodies, long cdrh3, hiv-1, immune system
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	147086.44
Authors	Pancera, M.,McLellan, J.,Zhou, T.,Zhu, J.,Kwong, P. (deposition date: 2010-04-19, release date: 2010-06-09, Last modification date: 2023-09-06)
Primary citation	Pancera, M.,McLellan, J.S.,Wu, X.,Zhu, J.,Changela, A.,Schmidt, S.D.,Yang, Y.,Zhou, T.,Phogat, S.,Mascola, J.R.,Kwong, P.D. Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1. J.Virol., 84:8098-8110, 2010 Cited by PubMed: 20538861 DOI: 10.1128/JVI.00966-10 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.97 Å)

Structure validation